Preliminary Study of Colistin versus Colistin plus Fosfomycin for Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections | Zendy

Rujipas Sirijatuphat | Zendy; Visanu Thamlikitkul | Zendy

Open Access

Preliminary Study of Colistin versus Colistin plus Fosfomycin for Treatment of Carbapenem-Resistant Acinetobacter baumannii Infections

Author(s) -

Rujipas Sirijatuphat,

Visanu Thamlikitkul

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02435-13

Subject(s) - colistin , fosfomycin , acinetobacter baumannii , carbapenem , medicine , antibiotics , acinetobacter , microbiology and biotechnology , biology , bacteria , pseudomonas aeruginosa , genetics

Ninety-four patients infected with carbapenem-resistant Acinetobacter baumannii were randomized to receive colistin alone or colistin plus fosfomycin for 7 to 14 days. The patients who received combination therapy had a significantly more favorable microbiological response and a trend toward more favorable clinical outcomes and lower mortality than those who received colistin alone. (This study has been registered at ClinicalTrials.gov under registration no. NCT01297894.).

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