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The complete nucleotide sequences of six IMP-4-encoding plasmids recovered fromEnterobacteriaceae isolates of wildlife origin were characterized. Sequencing data showed that plasmids of different incompatibility groups (IncM, IncI1, IncF, and nontypeable [including an IncX5_2 and two pPrY2001-like]) carried thebla IMP-4 -carrying integrons In809 or In1460. Most of the plasmids carried anmph (A) region, andchrA -like,aac(3)-IId , andbla TEM-1b genes. Finally, plasmid analysis revealed the involvement of two different IS26 - and Tn1696 -associated mechanisms in the mobilization of IMP-4-encoding integrons.

antimicrobial agents and chemotherapy

Characterization of the Complete Nucleotide Sequences of IMP-4-Encoding Plasmids, Belonging to Diverse Inc Families, Recovered from Enterobacteriaceae Isolates of Wildlife Origin