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An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC0–24 ) was 28.3 mg/liter · h. The AUC0–24 /MIC ratio for unbound concentrations and for sensitiveStaphylococcus andStreptococcus strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.

Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery