Spread of Clonally Related Escherichia coli Strains Harboring an IncA/C 1 Plasmid Encoding IMP-8 and Its Recruitment into an Unrelated MCR-1-Containing Isolate | Zendy

Alan Elena | Zendy; Daniela Cejas | Zendy; Francisco Magariños | Zendy; Virginia Jewtuchowicz | Zendy; Andrea Facente | Zendy; Gabriel Gutkind | Zendy; José Di Conza | Zendy; Marcela Rádice | Zendy

Open Access

Spread of Clonally Related Escherichia coli Strains Harboring an IncA/C ₁ Plasmid Encoding IMP-8 and Its Recruitment into an Unrelated MCR-1-Containing Isolate

Author(s) -

Alan Elena,

Daniela Cejas,

Francisco Magariños,

Virginia Jewtuchowicz,

Andrea Facente,

Gabriel Gutkind,

José Di Conza,

Marcela Rádice

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02414-17

Subject(s) - plasmid , escherichia coli , biology , mcr 1 , colistin , microbiology and biotechnology , enterobacteriaceae , escherichia coli proteins , genetics , gene , antibiotics

Ten IMP-8-producingEscherichia coli isolates were recovered from surveillance cultures of a neonatal intensive care unit; eight of the isolates were clonally related. A 168.2-kbbla IMP-8 plasmid was fully sequenced, and it corresponded to the recently described IncA/C1-ST13 plasmid. This plasmid was detected in all isolates, even in those that were not clonally related. One unrelated isolate was also resistant to colistin and positive formcr-1 . This marker was located in a 62.7-kb IncI2 plasmid, which was also fully sequenced.

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