Disruption of Biofilm Formation by the Human Pathogen Acinetobacter baumannii Using Engineered Quorum-Quenching Lactonases | Zendy

Jeng Yeong Chow | Zendy; Yuanyong Yang | Zendy; Song Buck Tay | Zendy; Kim Lee Chua | Zendy; Wen Shan Yew | Zendy

Open Access

Disruption of Biofilm Formation by the Human Pathogen Acinetobacter baumannii Using Engineered Quorum-Quenching Lactonases

Author(s) -

Jeng Yeong Chow,

Yuanyong Yang,

Song Buck Tay,

Kim Lee Chua,

Wen Shan Yew

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02410-13

Subject(s) - acinetobacter baumannii , biofilm , microbiology and biotechnology , quorum quenching , quorum sensing , human pathogen , pathogen , opportunistic pathogen , acinetobacter , biology , neisseriaceae , bacteria , chemistry , pseudomonas aeruginosa , antibiotics , genetics

Acinetobacter baumannii is a major human pathogen associated with multidrug-resistant nosocomial infections; its virulence is attributed to quorum-sensing-mediated biofilm formation, and disruption of biofilm formation is an attractive antivirulence strategy. Here, we report the first successful demonstration of biofilm disruption in a clinical isolate of A. baumannii S1, using a quorum-quenching lactonase obtained by directed evolution; this engineered lactonase significantly reduced the biomass of A. baumannii-associated biofilms, demonstrating the utility of this antivirulence strategy.

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