English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Pseudomonas aeruginosa is a prevalent and life-threatening Gram-negative pathogen.Pseudomonas -derived cephlosporinase (PDC) is the major inducible cephalosporinase inP. aeruginosa . In this investigation, we show that relebactam, a diazabicyclooctane β-lactamase inhibitor, potently inactivates PDC-3, with ak 2 /K of 41,400 M−1 s−1 and ak off of 0.00095 s−1 . Relebactam restored susceptibility to imipenem in 62% of multidrug-resistantP. aeruginosa clinical isolates, while only 21% of isolates were susceptible to imipenem-cilastatin alone. Relebactam promises to increase the efficacy of imipenem-cilastatin againstP. aeruginosa .

Inactivation of the Pseudomonas-Derived Cephalosporinase-3 (PDC-3) by Relebactam