Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae | Zendy

Alexander J. Lepak | Zendy; Miao Zhao | Zendy; Qingmei Liu | Zendy; Ping Wang | Zendy; Yanli Wang | Zendy; Justin Bader | Zendy; Paul G. Ambrose | Zendy; David R. Andes | Zendy

Open Access

Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae

Author(s) -

Alexander J. Lepak,

Miao Zhao,

Qingmei Liu,

Ping Wang,

Yanli Wang,

Justin Bader,

Paul G. Ambrose,

David R. Andes

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02404-18

Subject(s) - streptococcus pneumoniae , pharmacokinetics , staphylococcus aureus , microbiology and biotechnology , antibiotics , pneumonia , pharmacodynamics , area under the curve , medicine , methicillin resistant staphylococcus aureus , pharmacology , biology , bacteria , genetics

KBP-7072 is a novel aminomethylcycline antibiotic in clinical development for community-acquired pneumonia. The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the murine pneumonia infection model againstStaphylococcus aureus andStreptococcus pneumoniae .

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