Importance of Site of Infection and Antibiotic Selection in the Treatment of Carbapenem-Resistant Pseudomonas aeruginosa Sepsis | Zendy

Nicholas Britt | Zendy; David J. Ritchie | Zendy; Marin H. Kollef | Zendy; CareyAnn D. Burnham | Zendy; Michael J. Durkin | Zendy; Nicholas Hampton | Zendy; Scott T. Micek | Zendy

Open Access

Importance of Site of Infection and Antibiotic Selection in the Treatment of Carbapenem-Resistant Pseudomonas aeruginosa Sepsis

Author(s) -

Nicholas Britt,

David J. Ritchie,

Marin H. Kollef,

CareyAnn D. Burnham,

Michael J. Durkin,

Nicholas Hampton,

Scott T. Micek

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02400-17

Subject(s) - pseudomonas aeruginosa , sepsis , medicine , antibiotics , carbapenem , confidence interval , relative risk , urinary system , aminoglycoside , confounding , microbiology and biotechnology , biology , bacteria , genetics

In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection.

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