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Dalbavancin activity was assessed against a large collection ofStaphylococcus aureus isolates (n = 59,903), including isolates with decreased susceptibility to vancomycin (MIC, ≥2 mg/liter;n = 1,141), daptomycin (MIC, ≥2 mg/liter;n = 48), telavancin (MIC, ≥0.12 mg/liter;n = 52), teicoplanin (MIC, ≥4 mg/liter;n = 143), and/or linezolid (MIC, ≥8 mg/liter;n = 25). Dalbavancin displayed susceptibility rates ranging from 90.4% (isolates with telavancin MIC ≥0.12 mg/liter) to 100.0% (linezolid-resistant isolates) and lower MIC values than the comparators against these resistant subsets.

antimicrobial agents and chemotherapy

Antimicrobial Activity of Dalbavancin against Staphylococcus aureus with Decreased Susceptibility to Glycopeptides, Daptomycin, and/or Linezolid from U.S. Medical Centers