Antimicrobial Activity of Dalbavancin against Staphylococcus aureus with Decreased Susceptibility to Glycopeptides, Daptomycin, and/or Linezolid from U.S. Medical Centers | Zendy

Hélio S. Sader | Zendy; Rodrigo E. Mendes | Zendy; Leonard R Duncan | Zendy; Michael A. Pfaller | Zendy; Robert K. Flamm | Zendy

Open Access

Antimicrobial Activity of Dalbavancin against Staphylococcus aureus with Decreased Susceptibility to Glycopeptides, Daptomycin, and/or Linezolid from U.S. Medical Centers

Author(s) -

Hélio S. Sader,

Rodrigo E. Mendes,

Leonard R Duncan,

Michael A. Pfaller,

Robert K. Flamm

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02397-17

Subject(s) - dalbavancin , teicoplanin , linezolid , daptomycin , staphylococcus aureus , microbiology and biotechnology , vancomycin , liter , methicillin resistant staphylococcus aureus , antibacterial agent , broth microdilution , medicine , minimum inhibitory concentration , antimicrobial , antibiotics , biology , bacteria , genetics

Dalbavancin activity was assessed against a large collection ofStaphylococcus aureus isolates (n = 59,903), including isolates with decreased susceptibility to vancomycin (MIC, ≥2 mg/liter;n = 1,141), daptomycin (MIC, ≥2 mg/liter;n = 48), telavancin (MIC, ≥0.12 mg/liter;n = 52), teicoplanin (MIC, ≥4 mg/liter;n = 143), and/or linezolid (MIC, ≥8 mg/liter;n = 25). Dalbavancin displayed susceptibility rates ranging from 90.4% (isolates with telavancin MIC ≥0.12 mg/liter) to 100.0% (linezolid-resistant isolates) and lower MIC values than the comparators against these resistant subsets.

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