Open AccessTrichomonas vaginalis Metronidazole Resistance Is Associated with Single Nucleotide Polymorphisms in the Nitroreductase Genes ntr4 Tv and ntr6 Tv
Author(s) -
Teresa E. Paulish-Miller,
Peter Augostini,
Jessica A. Schuyler,
William L. Smith,
Eli Mordechai,
Martin E. Adelson,
Scott E. Gygax,
W. Evan Secor,
David W. Hilbert
Publication year - 2014
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02370-13
Subject(s) - trichomonas vaginalis , single nucleotide polymorphism , multilocus sequence typing , nitroreductase , trichomoniasis , biology , metronidazole , genetics , snp , gene , population , microbiology and biotechnology , genotype , medicine , antibiotics , gynecology , environmental health
Metronidazole resistance in the sexually transmitted parasite Trichomonas vaginalis is a problematic public health issue. We have identified single nucleotide polymorphisms (SNPs) in two nitroreductase genes (ntr4Tv and ntr6Tv) associated with resistance. These SNPs were associated with one of two distinct T. vaginalis populations identified by multilocus sequence typing, yet one SNP (ntr6Tv A238T), which results in a premature stop codon, was associated with resistance independent of population structure and may be of diagnostic value.
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