Macrolides Inhibit Capsule Formation of Highly Virulent Cryptococcus gattii and Promote Innate Immune Susceptibility | Zendy

Shigeki Nakamura | Zendy; Yurika Ikeda-Dantsuji | Zendy; Lianjin Jin | Zendy; Yoshitsugu Higashi | Zendy; Masahiro Abe | Zendy; Tatsuya Inukai | Zendy; Minoru Nagi | Zendy; Makoto Urai | Zendy; Yoshitsugu Miyazaki | Zendy

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Macrolides Inhibit Capsule Formation of Highly Virulent Cryptococcus gattii and Promote Innate Immune Susceptibility

Author(s) -

Shigeki Nakamura,

Yurika Ikeda-Dantsuji,

Lianjin Jin,

Yoshitsugu Higashi,

Masahiro Abe,

Tatsuya Inukai,

Minoru Nagi,

Makoto Urai,

Yoshitsugu Miyazaki

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02364-18

Subject(s) - cryptococcus gattii , innate immune system , biology , virulence , microbiology and biotechnology , pathogen , capsule , cryptococcosis , immunity , cryptococcus neoformans , immune system , cryptococcus , immunology , botany , biochemistry , gene

Cryptococcus gattii is a fungal pathogen, endemic in tropical and subtropical regions, the west coast of Canada, and the United States, that causes a potentially fatal infection in otherwise healthy individuals. Because the cryptococcal polysaccharide capsule is a leading virulence factor due to its resistance against innate immunity, the inhibition of capsule formation may be a promising new therapeutic strategy forC. gattii .

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