Open AccessA Small-Molecule Inhibitor of trans -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus
Author(s) -
Yueyang Huang,
John N. Alumasa,
Lauren T. Callaghan,
R. Samuel Baugh,
Christopher D. Rae,
Kenneth C. Keiler,
Shauna M. McGillivray
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02362-18
Subject(s) - staphylococcus aureus , cathelicidin , antibiotics , microbiology and biotechnology , antimicrobial , antibiotic resistance , antimicrobial peptides , biology , bacteria , translation (biology) , staphylococcal infections , staphylococcus , genetics , gene , messenger rna
Staphylococcus aureus is a leading cause of infection in the United States, and due to the rapid development of resistance, new antibiotics are constantly needed.trans -Translation is a particularly promising antibiotic target because it is conserved in many bacterial species, is critical for bacterial survival, and is unique among prokaryotes.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom