pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions | Zendy

Helen BillmanJacobe | Zendy; Yuhong Liu | Zendy; Ruth Haites | Zendy; Tom Weaver | Zendy; Lily Robinson | Zendy; Marc S. Marenda | Zendy; Mike DyallSmith | Zendy

Open Access

pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions

Author(s) -

Helen BillmanJacobe,

Yuhong Liu,

Ruth Haites,

Tom Weaver,

Lily Robinson,

Marc S. Marenda,

Mike DyallSmith

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02357-17

Subject(s) - salmonella enterica , plasmid , escherichia coli , microbiology and biotechnology , biology , mobile genetic elements , antibiotic resistance , salmonella , antibiotics , antimicrobial , enterobacteriaceae , genetics , gene , bacteria

Detailed annotation of an IncHI2 plasmid, pSTM6-275, from Salmonella enterica serotype 1,4,5,12:i:- strain TW-Stm6 revealed a composite structure, including antimicrobial resistance genes on mobile genetic elements. The plasmid was thermosensitive for transfer to Escherichia coli and conferred reduced susceptibility to antibiotics, copper sulfate, and silver nitrate. Metal ion susceptibility was dependent on physiological conditions, giving an insight into the environments where this trait might confer a fitness advantage.

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