Complete Sequence of a bla KPC-2 -Harboring IncFII K1 Plasmid from a Klebsiella pneumoniae Sequence Type 258 Strain | Zendy

Liang Chen | Zendy; Kalyan D. Chavda | Zendy; Roberto G. Melano | Zendy; Michael R. Jacobs | Zendy; Michael H. Levi | Zendy; Robert A. Bonomo | Zendy; Barry N. Kreiswirth | Zendy

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Complete Sequence of a bla _KPC-2 -Harboring IncFII _K1 Plasmid from a Klebsiella pneumoniae Sequence Type 258 Strain

Author(s) -

Liang Chen,

Kalyan D. Chavda,

Roberto G. Melano,

Michael R. Jacobs,

Michael H. Levi,

Robert A. Bonomo,

Barry N. Kreiswirth

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02332-12

Subject(s) - klebsiella pneumoniae , plasmid , sequence (biology) , strain (injury) , enterobacteriaceae , microbiology and biotechnology , klebsiella infections , biology , insertion sequence , virology , escherichia coli , gene , genetics , transposable element , genome , anatomy

We report the nucleotide sequence of a novel bla(KPC-2)-harboring IncFII(K1) plasmid, pBK32179, isolated from a carbapenem-resistant Klebsiella pneumoniae ST258 strain from a New York City patient. pBK32179 is 165 kb long, consists of a large backbone of pKPN3-like plasmid, and carries an 18.5-kb bla(KPC-2)-containing element that is highly similar to plasmid pKpQIL. pBK32179-like plasmids were identified in 8.3% of strains in a collection of 96 K. pneumoniae isolates from hospitals in the New York City area.

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