Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients | Zendy

René Welte | Zendy; Philipp Eller | Zendy; Ingo Lorenz | Zendy; Michael Joannidis | Zendy; Romuald Bellmann | Zendy

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Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients

Author(s) -

René Welte,

Philipp Eller,

Ingo Lorenz,

Michael Joannidis,

Romuald Bellmann

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02326-17

Subject(s) - pharmacokinetics , ascites , medicine , anidulafungin , critically ill , pleural effusion , effusion , pleural fluid , pharmacology , intensive care medicine , surgery , fluconazole , antifungal , micafungin , dermatology

Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulafungin levels in ascites fluid (0.12 to 0.99 μg/ml) and in pleural effusion (0.32 to 2.02 μg/ml) were below the simultaneous levels in plasma (1.04 to 7.70 and 2.48 to 13.36 μg/ml, respectively) and below the MIC values for several pathogenicCandida strains.

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