Open AccessEffect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis
Author(s) -
Narmada Fernando,
Rajiva de Silva,
Shiroma Handunnetti,
Lilani Karunanayake,
Nipun Lakshitha de Silva,
H Janaka de Silva,
Senaka Rajapakse,
Sunil Premawansa
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02312-17
Subject(s) - ceftriaxone , leptospirosis , antimicrobial , proinflammatory cytokine , medicine , doxycycline , penicillin , antibiotics , immunology , microbiology and biotechnology , inflammation , biology , pathology
The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (P = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses (P < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = −0.315;P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom