Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border | Zendy

David Saunders | Zendy; Suwanna Chaorattanakawee | Zendy; Panita Gosi | Zendy; Charlotte Lanteri | Zendy; Somethy Sok | Zendy; Worachet Kuntawunginn | Zendy; Mali Ittiverakul | Zendy; Soklyda Chann | Zendy; Carrie Gregory | Zendy; Char Meng Chuor | Zendy; Satharath Prom | Zendy; Michele Spring | Zendy; Chanthap Lon | Zendy

Open Access

Atovaquone-Proguanil Remains a Potential Stopgap Therapy for Multidrug-Resistant Plasmodium falciparum in Areas along the Thai-Cambodian Border

Author(s) -

David Saunders,

Suwanna Chaorattanakawee,

Panita Gosi,

Charlotte Lanteri,

Somethy Sok,

Worachet Kuntawunginn,

Mali Ittiverakul,

Soklyda Chann,

Carrie Gregory,

Char Meng Chuor,

Satharath Prom,

Michele Spring,

Chanthap Lon

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02302-15

Subject(s) - piperaquine , atovaquone , mefloquine , plasmodium falciparum , medicine , artemisinin , dihydroartemisinin , primaquine , pharmacology , proguanil , virology , malaria , chloroquine , immunology

Our recent report of dihydroartemisinin-piperaquine failure to treatPlasmodium falciparum infections in Cambodia adds new urgency to the search for alternative treatments. Despite dihydroartemisinin-piperaquine failure, and higher piperaquine 50% inhibitory concentrations (IC50 s) following reanalysis than those previously reported,P. falciparum remained sensitive to atovaquone (ATQ)in vitro . There were no point mutations in theP. falciparum cytochromeb ATQ resistance gene. Mefloquine, artemisinin, chloroquine, and quinine IC50 s remained comparable to those from other recent reports. Atovaquone-proguanil may be a useful stopgap but remains susceptible to developing resistance when used as blood-stage therapy.

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