PER-8, a Novel Extended-Spectrum β-Lactamase PER Variant, from an Acinetobacter baumannii Clinical Isolate in Nepal | Zendy

Tatsuya Tada | Zendy; Shovita Shrestha | Zendy; Kayo Shimada | Zendy; Hiroshi Ohara | Zendy; Jeevan Bahadur Sherchand | Zendy; Bharat Mani Pokhrel | Zendy; Teruo Kirikae | Zendy

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PER-8, a Novel Extended-Spectrum β-Lactamase PER Variant, from an Acinetobacter baumannii Clinical Isolate in Nepal

Author(s) -

Tatsuya Tada,

Shovita Shrestha,

Kayo Shimada,

Hiroshi Ohara,

Jeevan Bahadur Sherchand,

Bharat Mani Pokhrel,

Teruo Kirikae

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02300-16

Subject(s) - aztreonam , acinetobacter baumannii , imipenem , plasmid , microbiology and biotechnology , biology , antibiotics , bacteria , genetics , antibiotic resistance , gene , pseudomonas aeruginosa

A novel PER-type extended-spectrum β-lactamase, PER-8, was identified in anAcinetobacter baumannii clinical isolate obtained in Nepal. The amino acid sequence of PER-8 has a substitution at position 39 (Gly to Glu) compared with that of PER-7. Thek cat /Km ratio of PER-8 for aztreonam was lower than that of PER-7, while thek cat /Km ratio of PER-8 for imipenem was higher than that of PER-7. The genomic environment surroundingbla PER-8 wasintI1 bla PSE-1 qacEDI sulI ISCR1-bla PER-8 gts sulI orfX on a 100-kb plasmid.

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