IncFII Conjugative Plasmid-Mediated Transmission of bla NDM-1 Elements among Animal-Borne Escherichia coli Strains | Zendy

Dachuan Lin | Zendy; Miaomiao Xie | Zendy; Ruichao Li | Zendy; Kaichao Chen | Zendy; Edward WaiChi Chan | Zendy; Sheng Chen | Zendy

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IncFII Conjugative Plasmid-Mediated Transmission of bla _NDM-1 Elements among Animal-Borne Escherichia coli Strains

Author(s) -

Dachuan Lin,

Miaomiao Xie,

Ruichao Li,

Kaichao Chen,

Edward WaiChi Chan,

Sheng Chen

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02285-16

Subject(s) - plasmid , escherichia coli , biology , transmission (telecommunications) , microbiology and biotechnology , enterobacteriaceae , gene , genetics , virology , electrical engineering , engineering

This study aims to investigate the prevalence and transmission dynamics of the bla NDM-1 gene in animal Escherichia coli strains. Two IncFII bla NDM-1 -encoding plasmids with only minor structural variation in the MDR region, pHNEC46-NDM and pHNEC55-NDM, were found to be responsible for the transmission of bla NDM-1 in these strains. The bla NDM-1 gene can be incorporated into plasmids and stably inherited in animal-borne E. coli strains that can be maintained in animal gut microflora even without carbapenem selection pressure.

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