Open AccessStructure, Mechanism, and Inhibition of Aspergillus fumigatus Thioredoxin Reductase
Author(s) -
A.C. Marshall,
Sarah Kidd,
Stephanie J. Lamont-Friedrich,
Georgia Arentz,
Peter Hoffmann,
Bryan R. Coad,
John B. Bruning
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02281-18
Subject(s) - aspergillus fumigatus , thioredoxin reductase , mechanism (biology) , microbiology and biotechnology , reductase , biology , chemistry , biochemistry , enzyme , thioredoxin , philosophy , epistemology
Aspergillus fumigatus infections are associated with high mortality rates and high treatment costs. Limited available antifungals and increasing antifungal resistance highlight an urgent need for new antifungals.
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