Open AccessLinker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro , on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection
Author(s) -
Fritz Eichenseher,
Bjorn L. Herpers,
Paul Badoux,
Juan Manuel Leyva-Castillo,
Mathijs van der Zwart,
James McKellar,
Ferd Janssen,
Bob de Rooij,
Lavanja Selvakumar,
Christian Röhrig,
Johan Frieling,
Mark Offerhaus,
Martin J. Loessner,
Mathias Schmelcher
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02273-21
Subject(s) - staphylococcus aureus , microbiology and biotechnology , lysin , atopic dermatitis , skin infection , in vitro , biology , staphylococcal skin infections , epidermis (zoology) , staphylococcus , human skin , immunology , bacteria , escherichia coli , bacteriophage , biochemistry , genetics , anatomy , gene
Staphylococcus aureus causes a broad spectrum of diseases in humans and animals. It is frequently associated with inflammatory skin disorders such as atopic dermatitis, where it aggravates symptoms.