Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study | Zendy

Guohua An | Zendy; Daryl J. Murry | Zendy; Kiran Gajurel | Zendy; Thanh Bach | Zendy; Greg A. Deye | Zendy; Larissa V. Stebounova | Zendy; Ellen E. Codd | Zendy; John Horton | Zendy; Armando E. González | Zendy; Héctor H. Garcı́a | Zendy; Dilek İnce | Zendy; Denice HodgsonZingman | Zendy; Effie Nomicos | Zendy; Thomas Conrad | Zendy; Jessie K. Kennedy | Zendy; W. Jones | Zendy; Robert H. Gilman | Zendy; Patricia Winokur | Zendy

Open Access

Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study

Author(s) -

Guohua An,

Daryl J. Murry,

Kiran Gajurel,

Thanh Bach,

Greg A. Deye,

Larissa V. Stebounova,

Ellen E. Codd,

John Horton,

Armando E. González,

Héctor H. Garcı́a,

Dilek İnce,

Denice HodgsonZingman,

Effie Nomicos,

Thomas Conrad,

Jessie K. Kennedy,

W. Jones,

Robert H. Gilman,

Patricia Winokur

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02255-18

Subject(s) - oxfendazole , neurocysticercosis , anthelmintic , cysticercosis , tolerability , taenia solium , medicine , pharmacokinetics , pharmacology , placebo , taeniasis , adverse effect , cestode infections , veterinary medicine , immunology , pathology , helminths , fenbendazole , alternative medicine

Cysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of anthelmintic drugs, has demonstrated substantial activity against the tissue stages ofTaenia solium and has potential to be developed as an effective therapy for neurocysticercosis.

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