Detection of TR 34 /L98H CYP51A Mutation through Passive Surveillance for Azole-Resistant Aspergillus fumigatus in the United States from 2015 to 2017 | Zendy

Elizabeth L. Berkow | Zendy; Natalie S. Nunnally | Zendy; Alex Bandea | Zendy; R J Kuykendall | Zendy; Karlyn D. Beer | Zendy; Shawn R. Lockhart | Zendy

Open Access

Detection of TR ₃₄ /L98H CYP51A Mutation through Passive Surveillance for Azole-Resistant Aspergillus fumigatus in the United States from 2015 to 2017

Author(s) -

Elizabeth L. Berkow,

Natalie S. Nunnally,

Alex Bandea,

R J Kuykendall,

Karlyn D. Beer,

Shawn R. Lockhart

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02240-17

Subject(s) - aspergillus fumigatus , broth microdilution , azole , microbiology and biotechnology , biology , benzimidazole , aspergillus , population , mutation , chemistry , gene , minimum inhibitory concentration , antifungal , antibiotics , genetics , medicine , organic chemistry , environmental health

The emergence of azole-resistantAspergillus fumigatus has become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein Cyp51Ap contribute to this resistance, with the most concerning being the environmentally derived TR34 /L98H and TR46 /Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of theA. fumigatus population in the United States for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution, and five of those isolates harbored the TR34 /L98H mutation.

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