IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage | Zendy

Feifei Zhao | Zendy; Yu Feng | Zendy; Xiaoju Lü | Zendy; Alan McNally | Zendy; Zhiyong Zong | Zendy

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IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage

Author(s) -

Feifei Zhao,

Yu Feng,

Xiaoju Lü,

Alan McNally,

Zhiyong Zong

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02229-16

Subject(s) - klebsiella pneumoniae , mcr 1 , colistin , plasmid , microbiology and biotechnology , klebsiella infections , biology , klebsiella , sewage , enterobacteriaceae , gene , genetics , antibiotics , escherichia coli , environmental science , environmental engineering

A Klebsiella pneumoniae strain of sequence type 313 (ST313) recovered from hospital sewage was found carrying the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP-type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to spread beyond the Enterobacteriaceae family.

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