Open AccessEnhanced Efflux Pump Activity in Old Candida glabrata Cells
Author(s) -
Soma Bhattacharya,
Bettina C. Fries
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02227-17
Subject(s) - efflux , candida glabrata , microbiology and biotechnology , fluconazole , biology , chemistry , candida albicans , antifungal , biochemistry
We investigated the effect of replicative aging on antifungal resistance inCandida glabrata . Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus youngC. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase geneFKS1 and lower ergosterol content in older cells.
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