Biofilm Compared to Conventional Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Cystic Fibrosis Patients | Zendy

Kitty Wu | Zendy; Yvonne Yau | Zendy; Larissa Matukas | Zendy; Valerie Waters | Zendy

Open Access

Biofilm Compared to Conventional Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Cystic Fibrosis Patients

Author(s) -

Kitty Wu,

Yvonne Yau,

Larissa Matukas,

Valerie Waters

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02215-12

Subject(s) - stenotrophomonas maltophilia , colistin , cystic fibrosis , microbiology and biotechnology , antibiotics , levofloxacin , biofilm , pseudomonas aeruginosa , antimicrobial , stenotrophomonas , multiple drug resistance , biology , medicine , bacteria , pseudomonas , genetics

Stenotrophomonas maltophilia is a multidrug-resistant organism increasingly isolated from the lungs of cystic fibrosis (CF) patients. One hundred twenty-five S. maltophilia isolates from 85 CF patients underwent planktonic and biofilm susceptibility testing against 9 different antibiotics, alone and in double antibiotic combinations. When S. maltophilia isolates were grown as a biofilm, 4 of the 10 most effective antibiotic combinations included high-dose levofloxacin and 7 of the 10 combinations included colistin at doses achievable by aerosolization.

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