Open AccessArtemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages
Author(s) -
Dina Coertzen,
Janette Reader,
Mariëtte van der Watt,
Sindisiwe H. daba,
Liezl Gibhard,
Lubbe Wiesner,
Peter G. Smith,
Sarah D’Alessandro,
Donatella Taramelli,
Ho Ning Wong,
Jan L. du Preez,
Ronald Wai Keung Wu,
LynMarié Birkholtz,
Richard K. Haynes
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02214-17
Subject(s) - gametocyte , plasmodium falciparum , malaria , artemisinin , biology , plasmodium (life cycle) , virology , primaquine , drug resistance , immunology , parasite hosting , chloroquine , microbiology and biotechnology , world wide web , computer science
The emergence of resistance toward artemisinin combination therapies (ACTs) by the malaria parasitePlasmodium falciparum has the potential to severely compromise malaria control. Therefore, the development of new artemisinins in combination with new drugs that impart activities toward both intraerythrocytic proliferative asexual and transmissible gametocyte stages, in particular, those of resistant parasites, is urgently required.
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