Open AccessImpact of Preexisting Hepatitis C Virus Genotype 6 NS3, NS5A, and NS5B Polymorphisms on theIn VitroPotency of Direct-Acting Antiviral Agents
Author(s) -
Fiona McPhee,
Joseph Ueland,
Vincent Vellucci,
Scott Bowden,
William Sievert,
Nannan Zhou
Publication year - 2019
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02205-18
Subject(s) - ns5a , ns5b , ns3 , virology , hepatitis c virus , genotype , potency , hepacivirus , virus , biology , hepatitis c , in vitro , gene , genetics
HCV genotype 6 (GT-6) is found predominantly in East and Southeast Asia. Clinical studies have focused on patients infected with hepatitis C virus (HCV) GT-6a, where high sustained virologic response (SVR) rates to direct-acting antivirals (DAAs) have been achieved.
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