Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species | Zendy

Philippe Bidet | Zendy; Romain Basmaci | Zendy; Julien Guglielmini | Zendy; C. Doit | Zendy; Christelle Jost | Zendy; André Birgy | Zendy; Stéphane Bonacorsi | Zendy

Open Access

Genome Analysis of Kingella kingae Strain KWG1 Reveals How a β-Lactamase Gene Inserted in the Chromosome of This Species

Author(s) -

Philippe Bidet,

Romain Basmaci,

Julien Guglielmini,

C. Doit,

Christelle Jost,

André Birgy,

Stéphane Bonacorsi

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02192-15

Subject(s) - biology , gene , kingella kingae , genetics , plasmid , genome , strain (injury) , chromosome , microbiology and biotechnology , tetracycline , transposition (logic) , antibiotics , septic arthritis , anatomy , arthritis , immunology , linguistics , philosophy

We describe the genome of a penicillinase-producingKingella kingae strain (KWG1), the first to be isolated in continental Europe, whosebla TEM-1 gene was, for the first time in this species, found to be chromosomally inserted. Thebla TEM gene is located in an integrative and conjugative element (ICE) inserted in Met-tRNA and comprising genes that encode resistance to sulfonamides, streptomycin, and tetracycline. This ICE is homologous to resistance-conferring plasmids ofK. kingae and other Gram-negative bacteria.

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