Target Gene Sequencing To Define the Susceptibility of Neisseria meningitidis to Ciprofloxacin | Zendy

Eva Hong | Zendy; Sara Thulin Hedberg | Zendy; Raquel Abad | Zendy; Cecilia Fazio | Zendy; Rocío Enríquez | Zendy; AlaEddine Deghmane | Zendy; Keith A. Jolley | Zendy; Paola Stefanelli | Zendy; Magnus Unemo | Zendy; Julio A. Vázquez | Zendy; Frédéric J. Veyrier | Zendy; MuhamedKheir Taha | Zendy

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Target Gene Sequencing To Define the Susceptibility of Neisseria meningitidis to Ciprofloxacin

Author(s) -

Eva Hong,

Sara Thulin Hedberg,

Raquel Abad,

Cecilia Fazio,

Rocío Enríquez,

AlaEddine Deghmane,

Keith A. Jolley,

Paola Stefanelli,

Magnus Unemo,

Julio A. Vázquez,

Frédéric J. Veyrier,

MuhamedKheir Taha

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02184-12

Subject(s) - ciprofloxacin , neisseria meningitidis , microbiology and biotechnology , neisseriaceae , biology , neisseria , breakpoint , antibacterial agent , meningococcal disease , gene , bacteria , antibiotics , genetics , chromosomal translocation

MeningococcalgyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint forNeisseria meningitidis . Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥0.064 μg/ml but not among isolates with MICs of ≤0.032 μg/ml. Experimental infection of ciprofloxacin-treated mice showed slower bacterial clearance when GyrA was altered. These data suggest a MIC of ≥0.064 μg/ml as the ciprofloxacin breakpoint for meningococci and argue for the molecular detection of ciprofloxacin resistance.

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