Molecular Epidemiology of KPC-Producing Escherichia coli: Occurrence of ST131- fimH30 Subclone Harboring pKpQIL-Like IncFIIk Plasmid | Zendy

Jessica A. O’Hara | Zendy; Fupin Hu | Zendy; Chulsoo Ahn | Zendy; Jeremy B. Nelson | Zendy; Jesabel I. Rivera | Zendy; A. William Pasculle | Zendy; Yohei Doi | Zendy

Open Access

Molecular Epidemiology of KPC-Producing Escherichia coli: Occurrence of ST131- fimH30 Subclone Harboring pKpQIL-Like IncFIIk Plasmid

Author(s) -

Jessica A. O’Hara,

Fupin Hu,

Chulsoo Ahn,

Jeremy B. Nelson,

Jesabel I. Rivera,

A. William Pasculle,

Yohei Doi

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02182-13

Subject(s) - plasmid , escherichia coli , replicon , klebsiella pneumoniae , biology , microbiology and biotechnology , cole1 , enterobacteriaceae , trimethoprim , molecular epidemiology , gentamicin , genetics , antibiotics , gene , genotype

Of 20Klebsiella pneumoniae carbapenemase (KPC)-producingEscherichia coli isolates identified at hospitals in western Pennsylvania, 60% belonged to the epidemic ST131-fimH30 subclone. IncFIIk was the most common replicon type for thebla KPC -carrying plasmids (n = 8). All IncFIIk plasmids possessed a scaffold similar to that of pKpQIL, and seven of them were borne by ST131-fimH30 isolates. IncN plasmids conferred resistance to trimethoprim-sulfamethoxazole, and IncA/C plasmids conferred resistance to gentamicin. Threebla KPC -carrying plasmids (IncA/C and IncN) possessedbla SHV-7/12 andqnrA1 orqnrS1 .

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