In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria | Zendy

Evelyne Lacasse | Zendy; Éric Brouillette | Zendy; Audrey Larose | Zendy; Thomas Parr | Zendy; Aileen Rubio | Zendy; François Malouin | Zendy

Open Access

In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

Author(s) -

Evelyne Lacasse,

Éric Brouillette,

Audrey Larose,

Thomas Parr,

Aileen Rubio,

François Malouin

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02181-18

Subject(s) - penicillin binding proteins , gram negative bacteria , microbiology and biotechnology , penicillin , gram , enterobacteriaceae , carbapenem , cephalosporin , gram positive bacteria , bacteria , antibiotics , beta lactamase inhibitors , in vitro , biology , chemistry , escherichia coli , biochemistry , gene , genetics

Tebipenem (SPR859) is the microbiologically active form of SPR994 (tebipenem-pivoxil), an orally available carbapenem with activity against extended-spectrum β-lactamase (ESBL)-producingEnterobacteriaceae . Measurement of the relative binding of SPR859 to the bacterial cell targets revealed that it is a potent inhibitor of multiple penicillin-binding proteins (PBPs) but primarily a Gram-negative PBP 2 inhibitor, similar to other compounds in this class.

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