Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China | Zendy

Rong Zhang | Zendy; Dachuan Lin | Zendy; Edward WaiChi Chan | Zendy; Danxia Gu | Zendy; Gong-Xiang Chen | Zendy; Sheng Chen | Zendy

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Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China

Author(s) -

Rong Zhang,

Dachuan Lin,

Edward WaiChi Chan,

Danxia Gu,

Gong-Xiang Chen,

Sheng Chen

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02173-15

Subject(s) - klebsiella pneumoniae , serotype , microbiology and biotechnology , virulence , genotyping , biology , plasmid , virology , multiple drug resistance , klebsiella , carbapenem , gene , genotype , drug resistance , antibiotics , genetics , escherichia coli

We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne bla(KPC-2) gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.

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