Streptomycin Inhibits Quorum Sensing in Acinetobacter baumannii | Zendy

Sunil D. Saroj | Zendy; Philip N. Rather | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Streptomycin Inhibits Quorum Sensing in Acinetobacter baumannii

Author(s) -

Sunil D. Saroj,

Philip N. Rather

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02161-12

Subject(s) - quorum sensing , acinetobacter baumannii , streptomycin , microbiology and biotechnology , homoserine , autoinducer , gentamicin , biology , chemistry , antibiotics , bacteria , gene , biochemistry , pseudomonas aeruginosa , virulence , genetics

Streptomycin at subinhibitory concentrations was found to inhibit quorum sensing in Acinetobacter baumannii. Conditioned medium prepared by growth of A. baumannii in the presence of subinhibitory concentrations of streptomycin exhibited reduced activation of two quorum-sensing-regulated genes, abaI, encoding an autoinducer synthase, and A1S_0112. The reduced expression of AbaI resulted in greatly decreased levels of 3-OH-C(12)-HSL as confirmed by direct analysis using thin-layer chromatography. The effect on acyl-homoserine lactone (AHL) signal production was specific to streptomycin, as gentamicin and myomycin had no significant effect at subinhibitory levels.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research