Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance? | Zendy

Julien Ollivier | Zendy; C. Carrié | Zendy; Nicolas d’Houdain | Zendy; Sarah Djabarouti | Zendy; Laurent Petit | Zendy; Fabien Xuereb | Zendy; Rachel Legeron | Zendy; Matthieu Biais | Zendy; Dominique Breilh | Zendy

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Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?

Author(s) -

Julien Ollivier,

C. Carrié,

Nicolas d’Houdain,

Sarah Djabarouti,

Laurent Petit,

Fabien Xuereb,

Rachel Legeron,

Matthieu Biais,

Dominique Breilh

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02134-18

Subject(s) - ceftriaxone , medicine , dosing , pharmacokinetics , renal function , urology , pharmacodynamics , regimen , therapeutic drug monitoring , antibacterial agent , pharmacology , antibiotics , chemistry , biochemistry

The objective of the present study was to determine whether augmented renal clearance (ARC) impacts negatively on ceftriaxone pharmacokinetic (PK)/pharmacodynamic (PD) target attainment in critically ill patients. Over a 9-month period, all critically ill patients treated with ceftriaxone were eligible.

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