Sphingolipid Biosynthetic Pathway Genes FEN1 and SUR4 Modulate Amphotericin B Resistance | Zendy

Sushma Sharma | Zendy; Alfatah | Zendy; Vinay Kumar Bari | Zendy; Yashpal Rawal | Zendy; Sanjoy Paul | Zendy; K. Ganesan | Zendy

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Sphingolipid Biosynthetic Pathway Genes FEN1 and SUR4 Modulate Amphotericin B Resistance

Author(s) -

Sushma Sharma,

Alfatah,

Vinay Kumar Bari,

Yashpal Rawal,

Sanjoy Paul,

K. Ganesan

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02130-13

Subject(s) - sphingolipid , biology , saccharomyces cerevisiae , candida albicans , gene , amphotericin b , biosynthesis , microbiology and biotechnology , biochemistry , antifungal

Deletants of the sphingolipid biosynthetic pathway genesFEN1 andSUR4 ofSaccharomyces cerevisiae , as well as deletants of their orthologs inCandida albicans , were found to be 2- to 5-fold-more sensitive to amphotericin B (AmB) than parent strains. The inhibition of sphingolipid biosynthesis in parent strains by myriocin sensitized them to AmB, which can be reversed by providing phytosphingosine, an intermediate in the sphingolipid pathway. These results indicate that sphingolipids modulate AmB resistance, with implications for mechanisms underlying AmB action and resistance.

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