DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa | Zendy

Manoj Kumar | Zendy; Madhvi Rao | Zendy; Kedar Purnapatre | Zendy; Tarani Kanta Barman | Zendy; Vattan Joshi | Zendy; Amuliya Kashyap | Zendy; Tridib Chaira | Zendy; Ramesh B. Bambal | Zendy; Manisha Pandya | Zendy; Souhaila Al Khodor | Zendy; Dilip J. Upadhyay | Zendy; Nobuhisa Masuda | Zendy

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DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa

Author(s) -

Manoj Kumar,

Madhvi Rao,

Kedar Purnapatre,

Tarani Kanta Barman,

Vattan Joshi,

Amuliya Kashyap,

Tridib Chaira,

Ramesh B. Bambal,

Manisha Pandya,

Souhaila Al Khodor,

Dilip J. Upadhyay,

Nobuhisa Masuda

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02122-18

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , in vitro , drug resistance , biology , pseudomonadaceae , multiple drug resistance , urinary system , drug , pseudomonadales , biofilm , pharmacology , bacteria , biochemistry , endocrinology , genetics

DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum multidrug-resistantPseudomonas aeruginosa isolated from clinical samples andin vitro biofilms.

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