Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161 | Zendy

Brian C. Monk | Zendy; Mikhail V. Keniya | Zendy; M. Sabherwal | Zendy; Rajni K. Wilson | Zendy; Danyon O. Graham | Zendy; Harith F. Hassan | Zendy; Danni Chen | Zendy; Joel D. A. Tyndall | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Author(s) -

Brian C. Monk,

Mikhail V. Keniya,

M. Sabherwal,

Rajni K. Wilson,

Danyon O. Graham,

Harith F. Hassan,

Danni Chen,

Joel D. A. Tyndall

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02114-18

Subject(s) - tetrazole , lanosterol , azole , candida albicans , microbiology and biotechnology , chemistry , antifungal , biology , stereochemistry , biochemistry , sterol , cholesterol

Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain ofCandida albicans LDM in complex with the tetrazole VT-1161 has been obtained.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research