Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae | Zendy

Maria Fernanda Campagnari Bueno | Zendy; Gabriela Rodrigues Francisco | Zendy; Jessica A. O’Hara | Zendy; Doroti de Oliveira Garcia | Zendy; Yohei Doi | Zendy

Open Access

Coproduction of 16S rRNA Methyltransferase RmtD or RmtG with KPC-2 and CTX-M Group Extended-Spectrum β-Lactamases in Klebsiella pneumoniae

Author(s) -

Maria Fernanda Campagnari Bueno,

Gabriela Rodrigues Francisco,

Jessica A. O’Hara,

Doroti de Oliveira Garcia,

Yohei Doi

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02108-12

Subject(s) - klebsiella pneumoniae , methyltransferase , microbiology and biotechnology , 16s ribosomal rna , biology , klebsiella , bacteria , genetics , methylation , escherichia coli , dna , gene

EightKlebsiella pneumoniae clinical strains with high-level aminoglycoside resistance were collected from eight hospitals in São Paulo State, Brazil, in 2010 and 2011. Three of them produced an RmtD group 16S rRNA methyltransferase, RmtD1 or RmtD2. Five strains were found to produce a novel 16S rRNA methyltransferase, designated RmtG, which shared 57 to 58% amino acid identity with RmtD1 and RmtD2. Seven strains coproduced KPC-2 with or without various CTX-M group extended-spectrum β-lactamases, while the remaining strain coproduced CTX-M-2.

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