Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa | Zendy

Estela Ynés Valencia Morante | Zendy; Fernanda Esposito | Zendy; Beny Spira | Zendy; Jesús Blázquez | Zendy; Rodrigo S. Galhardo | Zendy

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Ciprofloxacin-Mediated Mutagenesis Is Suppressed by Subinhibitory Concentrations of Amikacin in Pseudomonas aeruginosa

Author(s) -

Estela Ynés Valencia Morante,

Fernanda Esposito,

Beny Spira,

Jesús Blázquez,

Rodrigo S. Galhardo

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02107-16

Subject(s) - amikacin , pseudomonas aeruginosa , ciprofloxacin , mutagenesis , sos response , microbiology and biotechnology , biology , antibacterial agent , antibiotics , chemistry , bacteria , mutation , escherichia coli , genetics , gene

Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis inPseudomonas aeruginosa .

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