Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole, Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species | Zendy

Anuradha Chowdhary | Zendy; Pradeep Kumar Singh | Zendy; Shallu Kathuria | Zendy; Ferry Hagen | Zendy; Jacques F. Meis | Zendy

Open Access

Comparison of the EUCAST and CLSI Broth Microdilution Methods for Testing Isavuconazole, Posaconazole, and Amphotericin B against Molecularly Identified Mucorales Species

Author(s) -

Anuradha Chowdhary,

Pradeep Kumar Singh,

Shallu Kathuria,

Ferry Hagen,

Jacques F. Meis

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02107-15

Subject(s) - posaconazole , mucorales , amphotericin b , voriconazole , antifungal , broth microdilution , microbiology and biotechnology , biology , mucormycosis , medicine , minimum inhibitory concentration , antibiotics , surgery

We compared EUCAST and CLSI antifungal susceptibility testing (AFST) methods for triazoles and amphotericin B against 124 clinical Mucorales isolates. The EUCAST method yielded MIC values 1- to 3-fold dilutions higher than those of the CLSI method for amphotericin B. The essential agreements between the two methods for triazoles were high, i.e., 99.1% (voriconazole), 98.3% (isavuconazole), and 87% (posaconazole), whereas it was significantly lower for amphotericin B (66.1%). Strategies for harmonization of the two methods for Mucorales AFST are warranted.

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