Risk Factors and Outcomes for Intestinal Carriage of AmpC-Hyperproducing Enterobacteriaceae in Intensive Care Unit Patients | Zendy

Simon Poignant | Zendy; Jérôme Guinard | Zendy; Aurélie Guigon | Zendy; Laurent Bret | Zendy; Didier-Marc Poisson | Zendy; Thierry Boulain | Zendy; François Barbier | Zendy

Open Access

Risk Factors and Outcomes for Intestinal Carriage of AmpC-Hyperproducing Enterobacteriaceae in Intensive Care Unit Patients

Author(s) -

Simon Poignant,

Jérôme Guinard,

Aurélie Guigon,

Laurent Bret,

Didier-Marc Poisson,

Thierry Boulain,

François Barbier

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02101-15

Subject(s) - enterobacteriaceae , carriage , intensive care unit , enterobacteriaceae infections , medicine , microbiology and biotechnology , intensive care medicine , biology , escherichia coli , gene , genetics , pathology

In a cohort of 1,209 intensive care unit (ICU) patients, the prevalence of intestinal colonization with high-level expressed AmpC cephalosporinase-producingEnterobacteriaceae (HLAC-PE) rose steadily from 2% at admission to 30% in patients with lengths of stay (LOS) exceeding 4 weeks. In multivariate analysis, LOS was the main predictor of carriage acquisition after adjustment on antimicrobial exposure. HLAC-PE infection occurred in 15% of carriers. Carriage and infection were associated with a marked increase in carbapenem consumption.

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