Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2′- C -Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection | Zendy

Luděk Eyer | Zendy; Martina Fojtíková | Zendy; Radim Nencka | Zendy; Ivo Rudolf | Zendy; Zdeněk Hubálek | Zendy; Daniel Růžek | Zendy

Open Access

Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2′- C -Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection

Author(s) -

Luděk Eyer,

Martina Fojtíková,

Radim Nencka,

Ivo Rudolf,

Zdeněk Hubálek,

Daniel Růžek

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02093-18

Subject(s) - virology , arbovirus , virus , biology , rna , viral replication , flavivirus , cytotoxicity , rna polymerase , west nile virus , biochemistry , in vitro , gene

West Nile virus (WNV) is a medically important emerging arbovirus causing serious neuroinfections in humans and against which no approved antiviral therapy is currently available. In this study, we demonstrate that 2′-C -methyl- or 4′-azido-modified nucleosides are highly effective inhibitors of WNV replication, showing nanomolar or low micromolar anti-WNV activity and negligible cytotoxicity in cell culture.

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