Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C | Zendy

Rachel Ulferts | Zendy; Lonneke van der Linden | Zendy; Hendrik Jan Thibaut | Zendy; Kjerstin Lanke | Zendy; Pieter Leyssen | Zendy; Bruno Coutard | Zendy; Armando M. De Palma | Zendy; Bruno Canard | Zendy; Johan Neyts | Zendy; Frank J. M. van Kuppeveld | Zendy

Open Access

Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C

Author(s) -

Rachel Ulferts,

Lonneke van der Linden,

Hendrik Jan Thibaut,

Kjerstin Lanke,

Pieter Leyssen,

Bruno Coutard,

Armando M. De Palma,

Bruno Canard,

Johan Neyts,

Frank J. M. van Kuppeveld

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02084-12

Subject(s) - fluoxetine , virology , serotonin reuptake inhibitor , rhinovirus , viral replication , biology , enterovirus , serotonin , virus , genetics , receptor

Although the genusEnterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.

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