First Report of KPC-2 Carbapenemase-Producing Klebsiella pneumoniae in Japan | Zendy

Ryoichi Saito | Zendy; R. Takahashi | Zendy; Etsuko Sawabe | Zendy; Saho Koyano | Zendy; Yutaka Takahashi | Zendy; Mari Shima | Zendy; Hiroto Ushizawa | Zendy; Toshihide Fujie | Zendy; Naoki Tosaka | Zendy; Yuko Kato | Zendy; Kyoji Moriya | Zendy; Shuji Tohda | Zendy; Naoko Tojo | Zendy; Ryuji Koike | Zendy; Tetsuo Kubota | Zendy

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First Report of KPC-2 Carbapenemase-Producing Klebsiella pneumoniae in Japan

Author(s) -

Ryoichi Saito,

R. Takahashi,

Etsuko Sawabe,

Saho Koyano,

Yutaka Takahashi,

Mari Shima,

Hiroto Ushizawa,

Toshihide Fujie,

Naoki Tosaka,

Yuko Kato,

Kyoji Moriya,

Shuji Tohda,

Naoko Tojo,

Ryuji Koike,

Tetsuo Kubota

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02072-13

Subject(s) - klebsiella pneumoniae , plasmid , microbiology and biotechnology , biology , strain (injury) , antibiotics , gene , enterobacteriaceae , virology , genetics , escherichia coli , anatomy

We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene blaKPC-2, which was present on the transferable plasmid of ca. 190 kb, in addition to the blaCTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-blaKPC-2-ISKpn6-like), encompassing blaKPC-2, were found to be similar to those of K. pneumoniae strains from China.

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