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MosaicpenA alleles have caused most of the cephalosporin resistance inNeisseria gonorrhoeae , but their evolution is mostly unknown. ThepenA gene fromNeisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 μg/ml) caused ceftriaxone resistance (MIC, 1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3′-terminal half of AM1601penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains.N. cinerea can serve as a reservoir of ceftriaxone resistance-mediatingpenA sequences that can be transferred to gonococci.

antimicrobial agents and chemotherapy

Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating <i>penA</i> Sequences in Neisseria gonorrhoeae

Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae