Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae | Zendy

Gene Igawa | Zendy; Yuka Yamagishi | Zendy; Kenichi Lee | Zendy; Misato Dorin | Zendy; Ken Shimuta | Zendy; Hiroyuki Suematsu | Zendy; Shuichi Nakayama | Zendy; Hiroshige Mikamo | Zendy; Magnus Unemo | Zendy; Makoto Ohnishi | Zendy

Open Access

Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae

Author(s) -

Gene Igawa,

Yuka Yamagishi,

Kenichi Lee,

Misato Dorin,

Ken Shimuta,

Hiroyuki Suematsu,

Shuichi Nakayama,

Hiroshige Mikamo,

Magnus Unemo,

Makoto Ohnishi

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02069-17

Subject(s) - ceftriaxone , neisseria gonorrhoeae , microbiology and biotechnology , cefixime , cephalosporin , antibacterial agent , neisseriaceae , biology , neisseria , gonorrhea , antibiotics , virology , bacteria , genetics , human immunodeficiency virus (hiv)

MosaicpenA alleles have caused most of the cephalosporin resistance inNeisseria gonorrhoeae , but their evolution is mostly unknown. ThepenA gene fromNeisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 μg/ml) caused ceftriaxone resistance (MIC, 1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3′-terminal half of AM1601penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains.N. cinerea can serve as a reservoir of ceftriaxone resistance-mediatingpenA sequences that can be transferred to gonococci.

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