Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients | Zendy

Yi He | Zendy; Lutan Zhou | Zendy; Chuanwen Gao | Zendy; Lei Han | Zendy; Yan Xu | Zendy

Open Access

Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients

Author(s) -

Yi He,

Lutan Zhou,

Chuanwen Gao,

Lei Han,

Yan Xu

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02069-16

Subject(s) - amphotericin b , antagonism , aspergillus flavus , microbiology and biotechnology , fusarium solani , fusarium , biology , keratitis , aspergillus , fungi imperfecti , antifungal , botany , biochemistry , receptor , genetics

Thein vitro activities of amphotericin B in combination with rifampin were assessed against 95 ocular fungal isolates. The interactions between amphotericin B and rifampin at 4, 8, 16, and 32 μg/ml were synergistic for 11.8%, 51.0%, 90.2%, and 94.1%, respectively, ofFusarium solani species complex isolates and for 13.6%, 45.5%, 93.2%, and 95.5%, respectively, ofAspergillus flavus species complex isolates. Antagonism was never observed for the amphotericin B-rifampin combinations.

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