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Thein vitro activities of amphotericin B in combination with rifampin were assessed against 95 ocular fungal isolates. The interactions between amphotericin B and rifampin at 4, 8, 16, and 32 μg/ml were synergistic for 11.8%, 51.0%, 90.2%, and 94.1%, respectively, ofFusarium solani species complex isolates and for 13.6%, 45.5%, 93.2%, and 95.5%, respectively, ofAspergillus flavus species complex isolates. Antagonism was never observed for the amphotericin B-rifampin combinations.

antimicrobial agents and chemotherapy

Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients