In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study | Zendy

Andrew Walkty | Zendy; James A. Karlowsky | Zendy; Melanie Baxter | Zendy; Heather J. Adam | Zendy; George G. Zhanel | Zendy

Open Access

In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study

Author(s) -

Andrew Walkty,

James A. Karlowsky,

Melanie Baxter,

Heather J. Adam,

George G. Zhanel

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02068-18

Subject(s) - microbiology and biotechnology , morganella morganii , broth microdilution , proteus mirabilis , proteus , gram , providencia , aminoglycoside , antimicrobial , staphylococcus aureus , medicine , enterobacteriaceae , biology , antibiotics , escherichia coli , minimum inhibitory concentration , bacteria , biochemistry , genetics , gene

The Clinical and Laboratory Standards Institute (CLSI) broth microdilution method was used to evaluate thein vitro activities of plazomicin and comparator antimicrobial agents against 7,712 Gram-negative and 4,481 Gram-positive bacterial pathogens obtained from 2013 to 2017 from patients in Canadian hospitals as part of the CANWARD Surveillance Study. Plazomicin demonstrated potentin vitro activity againstEnterobacteriaceae (MIC90 ≤ 1 µg/ml for all species tested exceptProteus mirabilis andMorganella morganii ), including aminoglycoside-nonsusceptible, extended-spectrum β-lactamase (ESBL)-positive, and multidrug-resistant (MDR) isolates.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research