Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth | Zendy

Antonia Efstathiou | Zendy; Nicolas GaboriaudKolar | Zendy; Vassilios Myrianthopoulos | Zendy; Konstantina Vougogiannopoulou | Zendy; Ines Subota | Zendy; Stephanie Aicher | Zendy; Emmanuel Mikros | Zendy; Philippe Bastin | Zendy; AlexiosLéandros Skaltsounis | Zendy; Ketty Soteriadou | Zendy; Despina Smirlis | Zendy

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Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth

Author(s) -

Antonia Efstathiou,

Nicolas GaboriaudKolar,

Vassilios Myrianthopoulos,

Konstantina Vougogiannopoulou,

Ines Subota,

Stephanie Aicher,

Emmanuel Mikros,

Philippe Bastin,

AlexiosLéandros Skaltsounis,

Ketty Soteriadou,

Despina Smirlis

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02065-18

Subject(s) - trypanosoma brucei , gsk 3 , biochemistry , biology , glycogen synthase , enzyme , gsk3b , kinase , chemistry , gene

The protozoan parasiteTrypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). The disease is fatal if it remains untreated, whereas most drug treatments are inadequate due to high toxicity, difficulties in administration, and low central nervous system penetration.

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