Open AccessRapid Emergence of Echinocandin Resistance during Candida kefyr Fungemia Treatment with Caspofungin
Author(s) -
Arnaud Fekkar,
I. Meyer,
JeanYves Brossas,
Éric Dannaoui,
M. Palous,
Madalina Uzunov,
Su Minh Tuyet Nguyen,
Véronique Leblond,
Dominique Mazier,
A. Datry
Publication year - 2013
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02037-12
Subject(s) - echinocandin , caspofungin , fungemia , echinocandins , medicine , drug resistance , microbiology and biotechnology , biology , antifungal , voriconazole , fluconazole
Echinocandin drugs are widely used for the treatment of candidemia. Resistance is considered rare, and only a few cases of breakthrough candidiasis in patients receiving echinocandin have been reported worldwide. We report here for the first time a Candida kefyr isolate that acquired echinocandin resistance very rapidly after the initiation of caspofungin treatment for candidemia. We characterized the FKS gene mutation responsible for the resistance via the comparison of isolates sampled before and during treatment.
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